Buy cheap Glucophage

Glucophage (Metformin) is an oral anti-diabetic drug from the biguanide class. It is the first-line drug of choice for the treatment of type 2 diabetes, particularly in overweight and obese people and those with normal kidney function. Glucophage (Metformin) is the most popular anti-diabetic drug in the United States and one of the most prescribed drugs in the country overall, with nearly 35 million prescriptions filled in 2006 for generic Glucophage (Metformin) alone. As of 2007, it is one of only two oral anti-diabetics in the World Health Organization Model List of Essential Medicines (the other being glibenclamide).

The main use for Glucophage (Metformin) is in the treatment of diabetes mellitus type 2, especially when this accompanies obesity and insulin resistance. Glucophage (Metformin) is the only anti-diabetic drug that has been proven to reduce the cardiovascular complications of diabetes, as shown in a large study of overweight patients with diabetes. Unlike the other most-commonly prescribed class of oral diabetes drugs, the sulfonylureas, Glucophage (Metformin) (taken alone) does not induce hypoglycemia. Hypoglycemia during intense exercise has been documented, but is extremely rare. It also does not cause weight gain, and may indeed produce minor weight loss. Glucophage (Metformin) also modestly reduces LDL and triglyceride levels.

It is also being used increasingly in polycystic ovarian syndrome (PCOS), non-alcoholic fatty liver disease (NAFLD) and premature puberty, three other diseases that feature insulin resistance; these indications are still considered experimental. Although Glucophage (Metformin) is not licenced for use in PCOS, the United Kingdom's National Institute for Health and Clinical Excellence recommends that women with PCOS and a body mass index above 25 be given Glucophage (Metformin) when other therapy has failed to produce results. The benefit of Glucophage (Metformin) in NAFLD has not been extensively studied and may be only temporary.

It may reduce weight gain in patients taking atypical antipsychotics.

The exact mechanism of action of Glucophage (Metformin) is uncertain, despite its known therapeutic benefits. It appears to act mainly by reducing hepatic gluconeogenesis, but it also decreases absorption of glucose from the gastrointestinal tract and increases insulin sensitivity by increasing peripheral utilization of glucose. The 'average' person with type 2 diabetes has three times the normal rate of gluconeogenesis; Glucophage (Metformin) treatment reduces this by over one third.

A 2001 study showed that Glucophage (Metformin) stimulates the hepatic enzyme AMP-activated protein kinase (AMPK), which plays an important role in the metabolism of fats and glucose. The molecular targets with which Glucophage (Metformin) directly interacts remain elusive.

Glucophage (Metformin) is not metabolized, rather it is primarily excreted in the urine with an elimination half-life of 6.2 hours.

What is the shelf life of the pills?

• The expiry date is mentioned on each blister. It is different for different batches. The shelf life is 2 years from the date of manufacture and would differ from batch to batch depending on when they were manufactured.