Buy cheap Geodon

Geodon (Ziprasidone) was the fifth atypical antipsychotic to gain FDA approval (February 2001). Geodon (Ziprasidone) is Food and Drug Administration (FDA) approved for the treatment of schizophrenia, and the intramuscular injection form of Geodon (Ziprasidone) is approved for acute agitation in schizophrenic patients. Geodon (Ziprasidone) has also received approval for acute treatment of mania associated with bipolar disorder.

The oral form of Geodon (Ziprasidone) is the hydrochloride salt, Geodon (Ziprasidone) hydrochloride. The intramuscular form, on the other hand, is the mesylate salt, Geodon (Ziprasidone) mesylate trihydrate, and is provided as a lyophilized powder.

Geodon (Ziprasidone) has a high affinity for dopamine, serotonin, and alpha-adrenergic receptors and a medium affinity for histaminic receptors. Geodon (Ziprasidone) also displays some inhibition of synaptic reuptake of serotonin and norepinephrine, although the clinical significance of this is unknown. The mechanism of action of Geodon (Ziprasidone) is unknown. However it has been theorized that its antipsychotic activity is mediated primarily by antagonism at dopamine receptors, specifically D2. Serotonin antagonism may also play a role in the effectiveness of Geodon (Ziprasidone), but the significance of 5-HT2A antagonism is debated among researchers. Geodon (Ziprasidone) has perhaps the most selective affinity for 5-HT2A receptors relative to D2 and 5-HT2C receptors of any neuroleptic, even greater than that of risperidone. Antagonism at histaminic and alpha adrenergic receptors likely explains some of the side effects of Geodon (Ziprasidone), such as sedation and orthostasis.

The systemic bioavailability of Geodon (Ziprasidone) administered intramuscularly is 100%, or 60%, administered orally with food. After a single dose intramuscular administration, the peak serum concentration typically occurs at about 60 minutes after the dose is administered, or earlier. Steady state plasma concentrations are achieved within one to three days. The mean half-life ranges from two to five hours. Exposure increases in a dose-related manner and following three days of intramuscular dosing, little accumulation is observed.

Geodon (Ziprasidone) absorption is not optimally achieved when administered without food. Without a meal preceding dose, the bioavailability of the drug is approximately 50-60%. At lower doses Geodon (Ziprasidone) may have a higher affinity for the 5-HT and Norepinephrine transmitter systems, which might be a factor in the activation into mania that is possible with the drug in patients with bipolar disorder.

What is the shelf life of the pills?

• The expiry date is mentioned on each blister. It is different for different batches. The shelf life is 2 years from the date of manufacture and would differ from batch to batch depending on when they were manufactured.