Most popular quantity. Coreg (Carvedilol) is a non-selective beta blocker indicated in the treatment of mild to moderate congestive heart failure (CHF). It is marketed under various trade names including Coreg (GSK), Dilatrend (Roche) and Eucardic (Roche), and (as of September 5, 2007 in the U.S.) as a generic drug.
Norepinephrine stimulates the nerves that control the muscles of the heart by binding to the ?1- and ?2-adrenergic receptors. Coreg (Carvedilol) blocks the binding to those receptors, which both slows the heart rhythm and reduces the force of the heart's pumping. This lowers blood pressure and reduces heart failure. Norepinephrine also binds to the ?1-adrenergic receptors on blood vessels, causing them to constrict and raise blood pressure. Coreg (Carvedilol) blocks this binding to the ?1-adrenergic receptors too, which also lowers blood pressure.
Relative to other beta blockers, Coreg (Carvedilol) has minimal inverse agonist activity (Vanderhoff et al., 1998). This suggests that Coreg (Carvedilol) has a reduced negative chronotropic and inotropic effect compared to other beta blockers, which may decrease its potential to worsen symptoms of heart failure. However, to date this theoretical benefit has not been established in clinical trials, and the current version of the ACC/AHA guidelines on congestive heart failure management does not give preference to Coreg (Carvedilol) over other beta-blockers. What is the shelf life of the pills?
- The expiry date is mentioned on each blister. It is different for different batches. The shelf life is 2 years from the date of manufacture and would differ from batch to batch depending on when they were manufactured.
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